Journal
FEBS LETTERS
Volume 579, Issue 11, Pages 2411-2415Publisher
WILEY
DOI: 10.1016/j.febslet.2005.03.040
Keywords
apoptosis repressor with caspase recruitment domain; apoptosis; cancer cells
Funding
- NCI NIH HHS [P30 CA43703] Funding Source: Medline
- NINDS NIH HHS [R01 NS39469] Funding Source: Medline
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Apoptosis repressor with caspase recruitment domain its expressed at high levels in brain and myogenic tissues, consisitent with a role to inhibit apoptosis in the terminally differentiated cells. Expression of ARC in cancers is not known. In this study, we reported that ARC was highly expressed in various non-myogenic and non-neurogenic human and rat cancer cell lines. Unexpectedly, ARC was localized almost exclusively to the nuclei of cancer cells, which was unlike the cytoplasmic localization of ARC in non-cancer cells. Furthermore, nuclear ARC in cancer cells did not co-localize with nucleolus protein of 30 kDa, an alternatively spliced ARC isoform. These findings indicate that ARC is distributed differently in cancer cells than non-cancer cells and thus might play a role in neoplastic transformation. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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