Journal
BRAIN RESEARCH
Volume 1042, Issue 1, Pages 114-118Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2005.01.097
Keywords
ketogenic diet; seizure; kainic acids; clusterin; apoptosis
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We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism. (c) 2005 Elsevier B.V. All rights reserved.
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