Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 57, Issue 6, Pages 857-867Publisher
ELSEVIER
DOI: 10.1016/j.addr.2005.01.005
Keywords
junctional adhesion molecule; tight junctions; cell adhesion; homophilic interactions; leukocyte migration; barrier function
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Funding
- NIGMS NIH HHS [T32 GM008169] Funding Source: Medline
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Junctional adhesion molecules (JAMs) are immunoglobulin superfamily (IgSF) proteins expressed at cell junctions in epithelial and endothelial cells as well as on the surface of leukocytes, platelets, and erythrocytes. Evidence suggests JAM proteins are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. This review will highlight what is currently known about the structure, function, and mechanism of action of JAM proteins as well as comment on potential directions for future JAM-related research. (c) 2005 Elsevier B.V. All rights reserved.
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