Journal
FEBS LETTERS
Volume 579, Issue 11, Pages 2284-2288Publisher
WILEY
DOI: 10.1016/j.febslet.2005.03.020
Keywords
insulin secretion; high-fat diet; fatty acid
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This study tests the hypothesis that islet peroxisome proliferator-activated receptor alpha (PPAR alpha) influences insulin secretion. Freshly isolated islets of normoglycemic PPAR alpha-null mice display no major alteration of glucose-stimulated insulin release. However, after 24 h of culture in high glucose, PPAR alpha-null islets exhibit elevated basal insulin secretion and fail to increase insulin mRNA. 24-h culture with palmitate replicates this phenotype in wild-type islets. The data suggest that PPAR alpha is needed to ensure appropriate insulin secretory response in situation of short-term hyperglycemia, likely by maintaining islet lipid homeostasis. As such, islet PPAR alpha could contribute to delay the progression of type 2 diabetes. alpha 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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