Journal
FEBS LETTERS
Volume 579, Issue 11, Pages 2327-2333Publisher
WILEY
DOI: 10.1016/j.febslet.2005.03.027
Keywords
peroxiredoxin; thioredoxin peroxidase; antioxidant enzyme; mitochondria; peroxide
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Peroxiredoxin 5 is a thioredoxin peroxidase ubiquitously expressed in mammalian tissues. Peroxiredoxin 5 can be addressed intracellularly to mitochondria, peroxisomes, the cytosol and the nucleus. Here, we show that mitochondrial human peroxiredoxin 5 protects mitochondrial DNA (mtDNA) from oxidative attacks. In an acellular assay, recombinant peroxiredoxin 5 was shown to protect plasmid DNA from damages induced by metal-catalyzed generation of reactive oxygen species. In Chinese hamster ovary cells, overexpression of mitochondrial peroxiredoxin 5 significantly decreased mtDNA damages caused by exogenously added hydrogen peroxide. Altogether our results suggest that mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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