Journal
CANCER LETTERS
Volume 221, Issue 2, Pages 185-190Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.11.012
Keywords
CYP1B1; GSTA1; NQO1; NAT2; lung cancer; smoking
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In a population-based case-cohort study, we have investigated the occurrence of lung cancer in relation to polymorphisms in the phase I gene cytochrome P450 1B1 and in the phase II genes glutathione S-transferase A1, NAD(P)H quinone oxidoreductase and N-acetyltransferase 2 (NAT2). Among 54,220 cohort members, 265 lung cancer cases were identified and a sub-cohort comprising 272 individuals was used for comparison. No overall associations were found between the polymorphisms and risk of lung cancer. The NAT2 fast acetylator genotype seemed to be protective against lung cancer in light smokers (<= 20 cigarettes/day) and not among heavy smokers (> 20 cigarettes/day). (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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