Anti-Mullerian hormone and folliculogenesis

This paper reviews the role of anti-Milllerian hormone, a member of the TGF beta family signaling through a BMP-like pathway, in the ovary. In vivo and in vitro studies showed that AMH has an inhibitory effect on primordial follicle recruitment and it decreases the sensitivity of follicles for the FSH-dependent selection for dominance. Besides its functional role in the ovary, AMH serum level serves as an excellent candidate marker of ovarian reserve. (c) 2005 Elsevier Ireland Ltd. All rights reserved.