Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 280, Issue 17, Pages 16546-16549Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.C400455200
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Funding
- NHLBI NIH HHS [R01 HL075092] Funding Source: Medline
- NIGMS NIH HHS [R01GM47214] Funding Source: Medline
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Mechanical tension is a critical determinant of cell growth, differentiation, apoptosis, migration, and development. Integrins have been implicated in sensing force but little is known about how forces are transduced to biochemical signals. We now show that mechanical strain stimulates conformational activation of integrin alpha v beta 3 in NIH3T3 cells. Integrin activation is mediated by phosphoinositol 3-kinase and is followed by an increase in integrin binding to extracellular matrix proteins. Mechanical stretch stimulation of JNK was dependent on new integrin binding to extracellular matrix. These data define a molecular mechanism for the role of integrins in mechanotransduction.
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