Journal
JOURNAL OF BACTERIOLOGY
Volume 187, Issue 9, Pages 2948-2956Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.187.9.2948-2956.2005
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Funding
- NIGMS NIH HHS [R01 GM047446, GM47446] Funding Source: Medline
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A Bacillus subtilis sigM null mutant, lacking the extracytoplasmic function sigma(M) protein, was sensitive to paraquat (PQ), a superoxide-generating reagent, but not to the redox stress-inducing compounds hydrogen peroxide, cumene hydroperoxide, t-butyl hydroperoxide, or diamide. Surprisingly, a sigM mutant was only sensitive to superoxide-generating compounds with a dipyridyl ring such as PQ, ethyl viologen, benzyl viologen, and diquat but not to menadione, plumbagin, pyrogallol, or nitrofurantoin. Mutational analysis of candidate sigma(M)-regulated genes revealed that both YqjL, a putative hydrolase, and BcrC, a bacitracin resistance protein, were involved in PQ resistance. Expression of yqiL, but not bcrC, from a xylose-inducible promoter restored PQ resistance to the sigM mutant.
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