Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 21, Issue 9, Pages 2600-2604Publisher
WILEY
DOI: 10.1111/j.1460-9568.2005.04077.x
Keywords
avoidance; CTA; knockout; learning; sweet
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Funding
- NIDA NIH HHS [T32 DA 07278] Funding Source: Medline
- NINDS NIH HHS [5 T32 NS 07332] Funding Source: Medline
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Conditioned taste aversion (CTA), is a form of Pavlovian learning wherein a novel flavour is powerfully associated with subsequent feelings of illness, and is afterwards avoided. In rats, pharmacological blockade of dopamine D1 receptors has been reported to prevent the expression of a CTA to the sweet taste of sucrose or saccharine. We used genetically modified mice to determine whether dopamine D1 receptors are necessary for the expression of a CTA. Food-deprived mice lacking the dopamine D1 receptor (D1r(-/-)) did not express a LiCl-induced (125 or 254 mg/kg) CTA to the sweet taste of 0.5 M sucrose, in agreement with previous pharmacological studies. However, water-deprived D1r(-/-) mice did express normal LiCl-induced (40, 150 and 254 mg/kg) CTA to a salty taste (0.2 M NaCl). Our results suggest that activation of D1 receptors might contribute to the strength of an aversive gustatory association, but might not be required for the formation of a CTA in general.
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