4.7 Article

Origin and dissemination of chloroquine-resistant Plasmodium falciparum with mutant pfcrt alleles in the Philippines

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 49, Issue 5, Pages 2102-2105

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.5.2102-2105.2005

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Funding

  1. NIAID NIH HHS [2R01- AI1047500, R01 AI047500] Funding Source: Medline

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The pfcrt allelic type and adjacent microsatellite marker type were determined for 82 Plasmodium falciparum isolates from the Philippines. Mutant pfcrt allelic types PI a and P2a/P2b were dominant in different locations. Microsatellite analysis revealed that P2a/P2b evolved independently in the Philippines, while P1a shared common ancestry with Papua New Guinea chloroquine-resistant parasites.

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