Analysis of magnetic drug carrier particle capture by a magnetizable intravascular stent-2: Parametric study with multi-wire two-dimensional model

A 2-D mathematical model was developed and used to examine the capture of magnetic drug carrier particles (MDCPs) by a magnetizable intravascular stent (MIS). The roles of both non-stent system parameters, i.e., the blood flow rate, magnetic field strength and direction and MDCP properties, and stent design parameters, i.e., the MIS radius, its wire radius, number of MIS loops, interwire loop spacing and MIS ferromagnetic material were evaluated over a wide range of plausible conditions. The results showed that the MIS could be a very effective magnetic drug targeting too] with many possible applications. (c) 2005 Published by Elsevier B.V.