Journal
CARDIOVASCULAR RESEARCH
Volume 66, Issue 2, Pages 222-232Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2005.02.009
Keywords
aging; mitochondria; permeability transition; reactive oxygen species; ischemia
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Mitochondria have been suggested to be causally linked to age-related alterations through respiratory chain dysfunction and formation of reactive oxygen species, leading to damage of mitochondrial DNA. Impaired biosynthesis of respiratory chain and ATP synthase subunits encoded by mitochondrial genes would set up a vicious cycle contributing to the aging process. Mitochondria are also involved in the increased susceptibility to ischemic injury observed in aged hearts, a process where the mitochondrial permeability transition pore (PTP) may play a role. Here, we analyze (i) the possible mechanisms through which PTP opening might contribute to age-related myocardial alterations; (ii) the available evidence of an increased probability of PTP opening in mitochondria isolated from aged tissues; (iii) the current methodological limitations that complicate the elucidation of causal relationships between PTP opening, mitochondrial dysfunction, and myocardial aging. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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