Journal
BIOSYSTEMS
Volume 80, Issue 2, Pages 175-184Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2004.11.005
Keywords
genetic code theories; coevolution; stereochemistry; error-minimization hypothesis; codon plurality; molecular weight of amino acids
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Funding
- NIGMS NIH HHS [GM48080] Funding Source: Medline
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A review of the main theories proposed to explain the origin of the genetic code is presented. I analyze arguments and data in favour of different theories proposed to explain the origin of the organization of the genetic code. It is possible to suggest a mechanism that makes compatible the different theories of the origin of the code, even if these are based on a historical or physicochemical determinism and thus appear incompatible by definition. Finally, I discuss the question of why a given number of synonymous codons was attributed to the amino acids in the genetic code. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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