Journal
CANCER IMMUNOLOGY IMMUNOTHERAPY
Volume 54, Issue 5, Pages 409-413Publisher
SPRINGER
DOI: 10.1007/s00262-004-0607-8
Keywords
cancer vaccines; gammopathy; myeloma; prevention; tumor immunity
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Preneoplastic lesions are more common than clinical cancer and define a population at increased risk for the development of malignancy. Recent studies suggest that the immune system has the capacity to recognize these lesions, and enrichment of preneoplasia-specific immune effectors can be detected in the tumor bed of some preneoplastic lesions such as monoclonal gammopathies. Here, I discuss the promise and challenges of harnessing the immune response against preneoplasia. Approaches to boost the natural host response to these lesions may have a major impact on reducing net cancer burden.
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