Journal
MECHANISMS OF DEVELOPMENT
Volume 122, Issue 5, Pages 659-669Publisher
ELSEVIER
DOI: 10.1016/j.mod.2004.12.008
Keywords
phox2b; enteric neuron; colorless; sox10; fate specification; progenitors; stem cells; neural crest; melanophore
Categories
Funding
- Medical Research Council [G0300415] Funding Source: Medline
- Medical Research Council [G0300415] Funding Source: researchfish
- MRC [G0300415] Funding Source: UKRI
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Zebrafish lacking functional sox10 have defects in non-ectomesenchymal neural crest derivatives including the enteric nervous system (ENS) and as such provide an animal model for human Waardenburg Syndrome IV. Here, we characterize zebrafish phox2b as a functionally conserved marker of the developing ENS. We show that morpholino-mediated knockdown of Phox2b generates fish modeling Hirschsprung disease. Using markers, including phox2b, we investigate the ontogeny of the sox10 ENS phenotype. As previously shown for melanophore development, ENS progenitor fate specification fails in these mutant fish. However, in addition, we trace back the sox10 mutant ENS defect to an even earlier time point, finding that most neural crest cells fail to migrate ventrally to the gut primordium. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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