Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 32, Pages 17826-17836Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b04168
Keywords
silver nanoparticles; magnesium; antibacteria; osteogenesis; plasma immersion ion implantation
Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [81301571, 81472109, 31370962]
- Interdisciplinary (Engineering-Medical) Research Fund of Shanghai Jiao Tong University [YG2011MS30]
- Shanghai Committee of Science and Technology, China [14XD1403900]
- Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201206SIC]
- Fund for Distinguished Young Doctors from Shanghai Municipal Commission of Health and Family Planning
- Youth Innovation Promotion Association CAS [2012196, 2015204]
- Shanghai Rising-Star Program [15QA1404100]
- Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University
- City University of Hong Kong Strategic Research Grant (SRG) [7004188]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) CityU [112212]
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To simultaneously enhance the osteogenic and antibacterial properties of titanium, we introduced magnesium (Mg), silver (Ag), or both by using the plasma immersion ion implantation (PIII) technique, producing three Pill sample groups, namely, Mg-doped titanium (Mg-PIII), Ag-doped titanium (Ag-PIII), and Mg and Ag codoped titanium (Mg/Ag-PIIIl). The in-vitro antibacterial efficacy of Mg/Ag Pill group was about 7-10% higher than that of Ag PIII. In vitro and in -vivo results demonstrated that osteogenic property of Mg/Ag PIII group was better than that of Ag Pill or Mg Pill. It was believed that the galvanic effects between Mg and Ag NPs played a key role in facilitating the release of Mg but reducing the release of silver, answering for the selective performances of the Mg/Ag Pill group over bacterial and mammalian cells. This study demonstrated that the integration of multiple functional elements could be realized by the dual-source PIII technique, and in this case, the antibacterial properties and osteogenic property of titanium could be balanced.
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