Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 37, Issue 5, Pages 1034-1042Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2004.08.013
Keywords
apoptosis; lymphocytes; aging; NF-kappa B; cIAPs; FADD; TNF receptors
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Funding
- NIA NIH HHS [AG-18313] Funding Source: Medline
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TNF-alpha, a pro-inflammatory cytokine, exerts its biological activity by signaling via its two receptors, TNFR-1 and TNFR-2 and by activating NF-kappa B. NF-kappa B is essential for survival of many cell types; however, TNF-alpha also induces cell death. During human aging TNF-alpha production and TNF-alpha-induced apoptosis are increased. In this brief review, we will discuss the TNF-alpha-mediated signaling and various molecular mechanisms underlying increased apoptosis in T cell subsets in aged humans with a special reference to alterations in transcription factor NF-kappa B and Fas-associated death domain (FADD). (c) 2004 Elsevier Ltd. All rights reserved.
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