Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 16, Issue 5, Pages 2275-2284Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.e04-10-0881
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01 AI051626, R01 AI051626-03, AI51626] Funding Source: Medline
Ask authors/readers for more resources
Polymerization of the actin cytoskeleton has been found to be essential for B-cell activation. We show here, however, that stimulation of BCR induces a rapid global actin depolymerization in a BCR signal strength-dependent manner, followed by polarized actin repolymerization. Depolymerization of actin enhances and blocking actin depolymerization inhibits BCR signaling, leading to altered BCR and lipid raft clustering, ERK activation, and transcription factor activation. Furthermore actin depolymerization by itself induces altered lipid raft clustering and ERK activation, suggesting that F-actin may play a role in separating lipid rafts and in setting the threshold for cellular activation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available