Journal
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION
Volume 33, Issue 3, Pages 169-176Publisher
WILEY
DOI: 10.1002/bmb.2005.494033032470
Keywords
allostery; monomeric proteins; myoglobin; albumin; thrombin
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Multimeric proteins ( e. g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins ( e. g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human alpha-thrombin, generally considered as molecular models of monomeric proteins, are summarized.
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