Cyclolignans from Scyphocephalium ochocoa via high-throughput natural product chemistry methods

Two 2,7 '-cyclolignans, ocholignans A and B, were obtained as mass-limited samples from Scyphocephalium ochocoa via high-throughput natural products chemistry methods. The rapid structure elucidation of each compound was primarily facilitated by NMR data acquisition using a capillary-scale NMR probe, CapNMR (TM) probe. Ocholignan A was found to possess significant in vitro antibacterial activity against Gram-positive bacteria methicillin-resistant Staphylococcus aureus ATCC 33591 and S. aureus 78-13607A with a MIC of 16 mu g/mL, respectively. (c) 2005 Elsevier Ltd. All rights reserved.