Journal
BIOMATERIALS
Volume 26, Issue 14, Pages 1857-1875Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2004.07.006
Keywords
micro-vascular; tissue engineering; capillary beds; tissue vascularisalion
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The construction of tissue-engineered devices for medical applications is now possible in vitro using cell culture and bioreactors. Although methods of incorporating them back into the host are available, current constructs depend purely on diffusion which limits their potential. The absence of a vascular network capable of distributing oxygen and other nutrients within the tissue-engineered device is a major limiting factor in creating vascularised artificial tissues. Though bio-hybrid prostheses such as vascular bypass grafts and skin substitutes have already been developed and are being used clinically. the absence of a capillary, bed linking the two systems remains the missing link. In this review, the different approaches currently being or that have been applied to vascularise tissues are identified and discussed. (C) 2004 Elsevier Ltd. All rights reserved.
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