Journal
NEUROBIOLOGY OF AGING
Volume 26, Issue 5, Pages 665-672Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.07.001
Keywords
glutamate; glutamine; aging; motor neurons; spectroscopy; 4T; metabolites
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Funding
- NIA NIH HHS [P50 AG023501-059004, P50 AG023501] Funding Source: Medline
- NINDS NIH HHS [R01 NS 30321, F32 NS043153, F32 NS43153] Funding Source: Medline
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Proton magnetic resonance spectroscopy was performed at 4 T to determine effects of age, region and gender on glutamate and glutamine in the normal human brain. Furthermore, glutamate and glutamine alterations with age were tested for correlations with other cerebral metabolites. Two 8cm(3) volumes were selected in corona radiata and mesial motor cortex in normal subjects (N = 24) between 24 and 68 years old. Older subjects had lower glutamate concentration in the motor cortex compared to younger subjects (p < 0.001). In corona radiata, older subjects demonstrated a trend in higher glutamine compared to younger subjects (p = 0.05). Glutamate in the motor cortex was positively correlated with glutamine, N-acetyl aspartate and creatine. Reduced glutamate and N-acetyl aspartate in the motor cortex is consistent with neuronal loss/shrinkage with age. In conclusion, different patterns in association with normal aging in these brain regions were detected in this study. (C) 2004 Published by Elsevier Inc.
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