Journal
MICROBES AND INFECTION
Volume 7, Issue 5-6, Pages 845-852Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2005.02.011
Keywords
Streptococcus pneumoniae; natural killer cells; bacteraemia; pneumonia
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Gram-positive sepsis is a major disease problem. However, the contribution of various immune cell types to pathogenesis remains unclear. By infecting scid and wild type BALB/c mice with Streptococcus pneumoniae we have found a situation in which natural killer (NK) cells can play a detrimental role in the response to infection. scid mice were found to be significantly more susceptible to local and systemic pneumococcal infection than controls; they had significantly higher bacterial loads, elevated inflammatory responses and more widespread lung pathology. Interestingly, depletion of NK cells in scid mice resulted in significantly lower bacteraemia and inflammatory cytokine production. Infection with pneumococci deficient in pneumolysin revealed the toxin was involved in cytokine production. Overall results indicate that elevated NK cell activity during pneumococcal pneumonia amplifies pulmonary and systemic inflammation, increases bacteraemia and results in poor outcome. (c) 2005 Elsevier SAS. All rights reserved.
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