Journal
CHEMBIOCHEM
Volume 6, Issue 5, Pages 848-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200400370
Keywords
abasic sites; DNA; phenanthroline; pyrene; stacking interactions
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Abasic sites represent a frequently occurring lesion in DNA. If not repaired, such lesions can lead to mutations or cell death. Stabilization of DNA containing abasic sites is investigated as a therapeutic approach for the treatment of cancer. Non-nucleosidic phenanthroline and pyrene derivatives were found to have a profound stabilizing effect (Delta T-m = 8 degrees C) on DNA missing a nucleobase.
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