Journal
JOURNAL OF NATURAL PRODUCTS
Volume 68, Issue 5, Pages 810-811Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0500979
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A new tetramic acid derivative, paecilosetin (1), along with a recently characterized N-hydroxypyridone, farinosone B (2), was isolated from the fungus Paecilomyces farinosus. Each compound showed activity against the P388 cell line with IC50 values of 3.1 and 1.1 mu g/mL, respectively. Paecilosetin was also active against the microorganisms Bacillus subtilis, Trichophyton mentagrophytes, and Cladosporium resinae.
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