Journal
NATURE NEUROSCIENCE
Volume 8, Issue 5, Pages 579-584Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1456
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Funding
- NIA NIH HHS [T32-AG023475, AG21654] Funding Source: Medline
- NIDDK NIH HHS [DK45024, DK48321, DK20541, DK47208] Funding Source: Medline
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Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.
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