FKBP immunophilin patents for neurological disorders

Immunophilins are a family of binding proteins that are highly conserved in nature and mediate the actions of immunosuppressant drugs. The FK-506-binding protein (FKBP) subclass of immunophilin bind FK-506 and rapamycin and are of particular interest due to their potent neurotrophic activity. Here, the patent literature covering the structures of novel non-immunosuppressant derivatives of FK-506 and rapamycin, and their claims pertaining to their potential use for the treatment of neurological disorders, are reviewed.