Journal
INFECTION AND IMMUNITY
Volume 73, Issue 5, Pages 3160-3163Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.5.3160-3163.2005
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A Brucella suis mgtC mutant is defective for growth within macrophages and in low-Mg2+ medium. These phenotypes are strikingly similar to those observed with mgtC mutants from Salmonella enterica and Mycobacterium tuberculosis, two other pathogens that proliferate within phagosomes. MgtC appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-Mg2+ environment in the phagosome.
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