Journal
WOUND REPAIR AND REGENERATION
Volume 13, Issue 3, Pages 243-247Publisher
WILEY
DOI: 10.1111/j.1067-1927.2005.130305.x
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A novel injectable scaffolding matrix (E-Matrix(TM)) has been developed to accelerate wound healing in diabetic foot ulcers. This porcine collagen-derived matrix is designed to mimic tertiary embryonic connective tissue and to stimulate fetal wound repair mechanisms including angiogenesis. In vitro and animal studies have indicated a beneficial effect on tissue growth and an acceptable safety profile. In this report, we describe the initial use of this product in a pilot study of six humans with chronic nonhealing diabetic foot ulcers. A dramatic initial response to injection was seen, with an average wound size reduction of 72% 2 weeks after injection. Randomized trials are underway to define the potential benefit of this new treatment modality for diabetic foot ulcers.
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