Journal
MICROBES AND INFECTION
Volume 7, Issue 5-6, Pages 962-967Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2005.03.009
Keywords
heterologous; prime-boost; vaccines; MVA; tuberculosis
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Funding
- Wellcome Trust [063643] Funding Source: Medline
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Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Heterologous prime-boost immunisation strategies induce higher levels of both CD4+ and CD8+ T cells than homologous boosting with the same vector. Recombinant pox-viruses are particularly good at boosting previously primed T cell responses. Using BCG as the priming immunisation in such a heterologous prime-boost strategy is a practical solution, which allows the beneficial effects of BCG in children to be maintained. (c) 2005 Elsevier SAS. All rights reserved.
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