Journal
APPLIED MAGNETIC RESONANCE
Volume 42, Issue 1, Pages 69-77Publisher
SPRINGER WIEN
DOI: 10.1007/s00723-011-0275-8
Keywords
-
Funding
- Ministry of Education, Culture, Sport, Science and Technology of Japan
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [11J00114] Funding Source: KAKEN
Ask authors/readers for more resources
To guarantee that organism's biological rhythms remain tied to the rhythms of its environment, the circadian clock must be able to reset itself in response to environmental cues. The main environmental stimulus for organisms is light, which is provided by day-night cycles. Cultured lines of zebrafish cells have been established as an attractive vertebrate cell-based model suitable for the examination of the light signaling pathway for entraining the circadian clock. Studies using these cell lines have revealed critical roles for the mitogen-activated protein kinase (MAPK) signaling pathways in light-dependent circadian entrainment. Here, we show in cultured zebrafish cells that artificial magnetic fields induce extracellular signal-regulated kinase (ERK)/MAPK activation with kinetics analogous to those elicited by light, suggesting that magnetic fields may influence circadian regulation in zebrafish. Our findings indicate that cultured zebrafish cells represent a valuable system for investigating the links between magnetic fields and the signaling pathways responsible for the synchronization of vertebrate circadian clocks under laboratory conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available