Hypercalcemia in a patient with common variable immunodeficiency and renal granulomas

Common variable Immunodeficiency (CVID) is the most common primary Immunodeficiency. A granulomatous form of the condition Is recognized. Renal Involvement Is rare. The authors present the first case of CVID with biopsy-proven noncaseating renal granulomas, In association with hypercalcemia. The mechanism of hypercalcemia In granulomatous disorders, and the difficulty of differentiating granulomatous CVID from sarcoidosis, are discussed.