Journal
ANALYTICAL CHEMISTRY
Volume 77, Issue 9, Pages 2940-2947Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac048512+
Keywords
-
Categories
Ask authors/readers for more resources
Solid-phase extraction (SPE) and liquid chromatography in combination with ion trap mass spectrometry (LC/MS/ MS) conditions were optimized for the simultaneous analysis of 13 antibiotics belonging to multiple classes and caffeine in 3 different water matrixes. The single-cartridge extraction step was developed using a reversed-phase cartridge, resulting in recoveries for the 14 compounds ranging from 71 to 119% with relative standard deviations of 16% or lower. The analytes were separated in one chromatographic run, and the SPE-LC/MS/MS detection limits ranged from 0.03 to 0. 19 mu g/L. The SPE procedure was validated in groundwater, surface water, and waste-water. The analysis of samples from each of the three water matrixes revealed clindamycin (1.1 mu g/L) in surface water and multiple antibiotics in wastewater (0.10-1.3 mu g/L). The use of identification points to unambiguously assign the identity of antibiotics in various water matrixes was applied to an ion trap data-dependent scanning method, which simultaneously collects full scan and full scan MS/MS data for the unequivocal identification of target analytes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available