Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 204, Issue 3, Pages 355-360Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2004.08.013
Keywords
dopamine transporter; neurotoxicity; human disease
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Funding
- NIDA NIH HHS [DA06470] Funding Source: Medline
- NIMH NIH HHS [MH47181] Funding Source: Medline
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The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD). (c) 2004 Published by Elsevier Inc.
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