Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 293, Issue 1, Pages 483-496Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2005.01.064
Keywords
superparamagnetic iron oxide nanoparticles (SPION); nanoparticles; magnetic drug targeting (MDT); immunomagnetic cell sorting (IMS); magnetic hyperthermia; toxicity; hyperthermia; review; contrast agent; nanoparticle functionalization; nanoparticle application
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Nanoparticles can be used in biomedical applications, where they facilitate laboratory diagnostics, or in medical drug targeting. They are used for in vivo applications such as contrast agent for magnetic resonance imaging (MRI), for tumor therapy or cardiovascular disease. Very promising nanoparticles for these applications are superparamagnetic nanoparticles based on a core consisting of iron oxides (SPION) that can be targeted through external magnets. SPION are coated with biocompatible materials and can be functionalized with drugs, proteins or plasmids. In this review, the characteristics and applications of SPION in the biomedical sector are introduced and discussed. (c) 2005 Elsevier B.V. All rights reserved.
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