Journal
MOLECULAR BIOTECHNOLOGY
Volume 30, Issue 1, Pages 57-69Publisher
HUMANA PRESS INC
DOI: 10.1385/MB:30:1:057
Keywords
blood-brain barrier (BBB); endothelium; drug delivery; genomics; proteomics
Funding
- NIMH NIH HHS [MH-61138] Funding Source: Medline
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Molecular biological investigations into the brain capillary endothelium and microvasculature, which forms the blood-brain barrier (BBB) in vivo, can provide the platform for the discovery and the molecular cloning of BBB-specific genes. Novel BBB genes can be discovered with either a genomics-based approach such as subtractive suppressive hybridization, or a proteomics approach using subtractive antibody expression cloning. BBB-specific genes are disproportionately transporter genes encoding either for carrier-mediated transporters, active efflux transporters, or receptor-mediated transporters. The discovery of new BBB transporters can lead to the development of new approaches to brain drug delivery using endogenous brain endothelial transporters.
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