Journal
BIOCHEMISTRY-MOSCOW
Volume 70, Issue 5, Pages 559-567Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1007/s10541-005-0149-5
Keywords
DNA methylation; molecular evolution; comparative genomics; gene duplications; position effects; genetic complexity
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Consideration of epigenetic silencing, perhaps by DNA methylation, led to an epigenetic complementation (EC) model for evolution by gene duplication (Rodin and Riggs (2003) J. Mol Evol, 56, 718-729). This and subsequent work on genome-wide analyses of gene duplicates in several eukaryotic species pointed to a fundamental link between localization in the genome, epigenetic regulation of expression, and the evolutionary fate of new redundant gene copies, which can be either non- or neo-functionalization. Our main message in this report is that repositioning of a new duplicate to an ectopic site epigenetically alters its expression pattern, and concomitantly the rate and direction of mutations. Furthermore, comparison of syntenic vs. non-syntenic pairs of gene duplicates of different age unambiguously indicates that repositioning saves redundant gene duplicates from pseudogenization and hastens their evolution towards a new development-time and tissue-specific pattem of function.
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