Journal
CANCER RESEARCH
Volume 65, Issue 9, Pages 3535-3537Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-05-0104
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- NCI NIH HHS [CA46120] Funding Source: Medline
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Galectin-3 (gal-3), a member of the beta-galactoside-binding proteins family, was identified as a binding partner of catenin. Analysis of the human gal-3 sequence reveled a structural similarity to beta-catenin as it also contains the consensus sequence (S92XXXS96) for glycogen synthase kinase-3 beta (GSK-3 beta) phosphorylation and can serve as its substrate. In addition, Axin, a regulator protein of Wnt that complexes with beta-catenin, also binds gal-3 using the same sequence motif identified here by a deletion mutant analysis. The data presented here give credence to the suggestion that gal-3 is a key regulator in the Wnt/ beta-catenin signaling pathway and highlight the functional similarities between gal-3 and beta-catenin.
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