Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 293, Issue 1, Pages 509-513Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2005.01.066
Keywords
apoferritin; doxorubicin; encapsulation; ferritin; chemotherapy
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The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin-HCl gives rise to a solution containing five doxorubicin-HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-cancer drug into its cavity. (c) 2005 Published by Elsevier B.V.
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