Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 28, Issue 5, Pages 509-517Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02977751
Keywords
pyridazinone; pyrazole; analgesic; anti-inflammatory; writhing; carrageenan
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A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4-chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.
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