Journal
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume 57, Issue 5, Pages 657-659Publisher
WILEY
DOI: 10.1211/0022357055858
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The inhibitory effect of oracin on the activities of topoisomerases I and II isolated from the nuclei of mice liver tissue was studied. This drug showed a 100% inhibitory effect at 5 mu M and 50% inhibition at 1 mu M on topoisomerase II activity, while the activity of topoisomerase I at these concentrations was not inhibited.
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