Journal
NATURE REVIEWS GENETICS
Volume 6, Issue 5, Pages 389-402Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg1606
Keywords
-
Categories
Funding
- Wellcome Trust [074454] Funding Source: Medline
Ask authors/readers for more resources
The human mitochondrial genome is extremely small compared with the nuclear genome, and mitochondrial genetics presents unique clinical and experimental challenges. Despite the diminutive size of the mitochondrial genome, mitochondrial DNA ( mtDNA) mutations are an important cause of inherited disease. Recent years have witnessed considerable progress in understanding basic mitochondrial genetics and the relationship between inherited mutations and disease phenotypes, and in identifying acquired mtDNA mutations in both ageing and cancer. However, many challenges remain, including the prevention and treatment of these diseases. This review explores the advances that have been made and the areas in which future progress is likely.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available