Journal
CELL CALCIUM
Volume 37, Issue 5, Pages 507-511Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2005.01.018
Keywords
VGCC; GPCR; CNS
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Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha 1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function. (c) 2005 Elsevier Ltd. All rights reserved.
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