Journal
DRUG DISCOVERY TODAY
Volume 10, Issue 9, Pages 617-625Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(05)03394-5
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Current safety screening of drug candidates or new chemical entities for reactive metabolite formation focuses on the role of cytochrome P450. However, peroxidases also have a major role in drug metabolism, and peroxidase-catalyzed drug oxidation could lead to reactive metabolite formation, resulting in oxidative stress and cytotoxicity. Here, the different classes of human peroxidases are summarized and the molecular mechanisms of peroxidase-catalyzed drug metabolism are discussed. In addition, evidence is presented that indicates a role of these enzymes in drug toxicity.
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