Journal
HYPERTENSION
Volume 45, Issue 5, Pages 997-1003Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.HYP.0000165018.63523.8a
Keywords
arteriosclerosis; hypertension, obesity; immune systems; insulin resistance
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We examined whether the presence of an increasing number of metabolic syndrome disorders was associated with an increasing pulse wave velocity, which is recognized as a marker of cardiovascular risk, and evaluated whether an elevated plasma C-reactive protein level augments this increasing pulse wave velocity. Using a cross-sectional study design, C-reactive protein, metabolic syndrome-related anthropometric parameters, and pulse wave velocity were measured in 5752 middle-aged Japanese men (44 +/- 10 years old). In linear regression analyses, all of the metabolic disorders and the logarithm of the C-reactive protein significantly correlated with pulse wave velocity. Multiple linear regression analysis demonstrated that triglycerides, HDL cholesterol, mean blood pressure, fasting glucose, and the logarithm of the C-reactive protein were significant independent positive predictors of pulse wave velocity (R-square=0.38). The presence of an increasing number of metabolic disorders in the subjects was associated with an increasing pulse wave velocity (no disorders 1228 +/- 139 cm/s >= 3 disorders 1437 +/- 250 cm/s; P < 0.01). Among subjects with the metabolic syndrome, pulse wave velocity was higher in cases with (1508 +/- 278 cm/s) than in those without an elevated C-reactive protein (1427 +/- 243 cm/s; P < 0.01). In conclusion, an increase in arterial stiffness may constitute a pathophysiological basis for the increased risk of cardiovascular disease in patients with the metabolic syndrome and that an elevated C-reactive protein level may aggravate this cardiovascular risk.
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