Journal
CHEMBIOCHEM
Volume 6, Issue 5, Pages 821-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200400374
Keywords
cyclization; epitope mapping; peptides; peptidomimetics; protein models
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No need for side-chain protection in the cyclization reaction of cysteine-containing linear peptides onto bromo-methylated aromatic scaffolds (see scheme). The reaction is extremely fast and clean and runs to completion in less than 15 min at room temperature.
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