Journal
JOURNAL OF CLINICAL PHARMACOLOGY
Volume 45, Issue 5, Pages 570-577Publisher
WILEY
DOI: 10.1177/0091270004274432
Keywords
exenatide; exendin-4; type 2 diabetes; pharmacokinetics
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Exenatide is an incretin mimetic with potential glucoregulatory activity in type 2 diabetes. This randomized, single-blind, placebo-con trolled 6-way crossover study assessed exenatide's effect on acetaminophen pharmacokinetics. Of 40 randomized healthy subjects, 39 completed the study. On the placebo day, acetaminophen (1000 mg) was ingested and placebo injected subcutaneously at 0 hours. On exenatide days, acetaminophen was ingested at -1, 0, + 1, +2, and +4 hours, relative to the 10 mu g exenatide injected subcutaneously at 0 hours. With exenatide injection, mean plasma acetaminophen AUC(0-12) h values were reduced by 11% to 24 % (vs placebo). Peak plasma acetaminophen concentrations were similar for the -1-hour and placebo groups and reduced by 37% to 56% at other times. The most frequent adverse events were generally mild to moderate nausea and vomiting. Exenatide treatment concurrent with or preceding acetaminophen ingestion slowed acetaminophen absorption but had minimal effect on the extent of absorption.
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