Journal
BIOESSAYS
Volume 27, Issue 5, Pages 467-471Publisher
WILEY
DOI: 10.1002/bies.20232
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Funding
- NICHD NIH HHS [HD-045595] Funding Source: Medline
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Many kinds of multifunctional regulatory proteins have been identified that perform distinct biochemical functions in the nucleus, the cytoplasm, or both. Here we describe the recent discovery by Hall et al. (2004)((1)) of a new type of multifunctional protein: a metabolic enzyme that doubles as a transcription factor. This enzyme, Arg5,6, functions as a catalytic enzyme in ornithine biosynthesis and also binds and regulates the promoters of nuclear and mitochondrial genes. It may also regulate precursor mRNA metabolism. We discuss how proteins that serve as both metabolic enzymes and transcription factors might have evolved.
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