Journal
TRENDS IN IMMUNOLOGY
Volume 26, Issue 5, Pages 242-247Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2005.03.005
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It is often argued that T cell-mediated immunity to secondary infection is dependent on the 'accelerated', responses of memory T cells in lymph nodes. However, new evidence points to a crucial role for effector memory T cells, which are resident in peripheral tissues, in immune protection. These T cells, which reside in peripheral tissues, are not necessarily bound by an anatomical structure and can be present at many sites. Collectively, they represent a third functional tissue of the immune system, uniquely specialized to mediate protective immunity. We propose that the paradigm 'effector lymphoid tissue' needs to be articulated and developed as a focus of new research to describe and understand the unique role this tissue has in protective immunity.
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